Have you ever seen what a 22-250 does to a Jack Rabbit, it vaporizes them and does the same internally to a deer!
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People say the minimum caliber for deer is .243, and lots of folks say the .22 centerfires are to small, but does the extra .023
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Put another way, the direct answer to this question is NO. The difference in diameter should not make any difference in performance, if that is the only variable in the comparison. Given bullets of identical weight, type and construction (and moving at identical velocities) as being constant, the performance should be (almost) identical. The problem is availability of .223 and .243 bullets in identical bullet weights.
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It's all about the bullet selection. A lot of the bad rap a .243 gets is a result of selecting the wrong bullet. The Federal 85 grain BTHP or the Remingtin 100 grain core lokt ultra factory will drop them consistently. Not that those are the only two, but the point is that if you choose the same grain but wrong bullet, and you may have expansion problems and lost deer. These two are proven deer-droppers.
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